This is not grilling; grilling is simply cooking on a grill. This is barbecue.
Generally, beef barbecue entails cooking meat low and slow in dry heat, likely over wood.
Beyond that, it is a gigantic and highly contentious topic, subject to regional rivalries and the fervent proclamations of the true believers. Get a helmet, kids.
In the meantime, barbecuing a whole packer brisket is a very doable -- and wildly fun -- thing to do. Get some details here.